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G6B (Protein G6b, C6orf25)

G6B (Protein G6b, C6orf25)

Cat no: G0900-24

Supplier: United States Biological
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G6B is a 241aa novel regulatory nuclear chloride ion channel protein belonging to the immunoglobulin (Ig) super family. It is a glycosylated receptor, present both as soluble and transmembrane isoforms where the soluble proteins show expression in endoplasmic reticulum and Golgi before being secreted. It contains a leader sequence and an extracellular Ig domain which binds to heparin and helps to modulate the interaction of G6B with an unknown protein ligand. It also has an intracellular, proline-rich potential SH3-binding domain, and two putative phosphorylated tyrosine motifs with an SH2-binding domain that is recruited to the receptor and dephosphorylates membrane-bound phosphoproteins and thus modulates the signaling cascade. It is commonly expressed in certain hematopoietic cell lines including K562, Molt4, and Jurkat. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: K562 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G0900-24
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. de Vet, ECJM, et al. J. Biol. Chem. 276:42070-42076 (2001). 2. Ribas, G. et al. J. Immun. 163:278-287 (1999). 3. de Vet, ECJM. et al. FEBS Lett. 579:2355-2358 (2005).
Additional info: Recognizes human G6B. Species Crossreactivity: chimpanzee. Species sequence homology: mouse, rat, bovine, canine, monkey.

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