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Gab1, phosphorylated (Tyr659) (GRB2-associated-binding Protein 1, GRB2-associated Binder 1, Growth Factor Receptor Bound Protein 2-associated Protein 1)

Gab1, phosphorylated (Tyr659) (GRB2-associated-binding Protein 1, GRB2-associated Binder 1, Growth Factor Receptor Bound Protein 2-associated Protein 1)

Cat no: G1012-10H

Supplier: United States Biological
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GRB-associated binder (Gab) is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs), such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane, undergoes phosphorylation and functions as a multiprotein assembling center. Multiple tyrosine phosphorylation sites of Gab1 protein have been identified. Phosphorylation of tyrosine 472 regulates its binding to p85 PI3 kinase. Phosphorylation of tyrosines 307, 373 and 407 modulates the association to PLCgamma. Phosphorylation of tyrosines 627 and 659 are required for the binding and activation of protein tyrosine phosphatase SHP2. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:4,000 Western Blot: 1:500-1:1,000 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G1012-10H
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human Gab1 when phosphorylated at tyrosine 659. Species Cross-Reactivity: mouse, rat.

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