GABA A Receptor alpha 4 (GABA(A) receptor subunit alpha 4, GABR A4, GABRA4, Gamma aminobutyric acid (GABA) A receptor alpha 4)

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.\nGABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. \n\n

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SPECIFICATIONS

Catalog Number

G1015-07G3

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Rat

Form

10mM Hepes (pH 7.5), 150 mM NaCl, 100 ug/ml BSA, and 50% glycerol

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Bencsits, E., et al, A significant part of native gamma-aminobutyric acid-A receptors containing alpha 4 subunits do not contain gamma or delta subunits. J. Biol. Chem.. 274: 19613-6, 1999

Additional Info

Reacts with the N-terminus of the 64kD alpha 4 subunit of rat brain GABA-A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits. Species Crossreactivity: This antibody reacts with rat. Other species have not been tested.

Alternative Names

GABA(A) receptor subunit alpha 4, GABR A4, GABRA 4, GABRA4, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor subunit alpha 4