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GABA A receptor alpha 5 subunit

GABA A receptor alpha 5 subunit

Cat no: G1015-07K

Supplier: United States Biological
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GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G1015-07K
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: 10mM Hepes (pH 7.5), 150 mM NaCl, 100 ug/ml BSA, and 50% glycerol.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Maison, S. F., Rosahl, T. W., Homanics, G. E., and Liberman, M. C. (2006) Functional Role of GABAergic Innervation of the Cochlea: Phenotypic Analysis of Mice Lacking GABAA Receptor Subunits {alpha}1, {alpha}2, {alpha}5, {alpha}6, beta2, beta3, or {delta}, 26, 10315-10326.
Additional info: Reacts with the C-terminus of the 55kD alpha 5 subunit of rat brain GABA-A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits. Species Crossreactivity: This antibody reacts with rat and mouse. Other species have not been tested.

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