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GABA A receptor alpha 6 subunit

GABA A receptor alpha 6 subunit

Cat no: G1015-08J

Supplier: United States Biological
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GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The alpha 6 subunit is expressed in cerebellar granule cells. Though it is concentrated at synapses, it is found on extrasynaptic membranes, as well. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G1015-08J
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: 10 mM Hepes [pH 7.5], 150 mM sodium chloride, 100 ug/ml BSA, 50% glycerol.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Nusser, Z., et al. Alterations in the expression of GABA-A receptor subunits in cerebellar granule cells after the disruption of the alpha 6 subunit gene. Eur. J. Neurosci. 11: 1685-97 (1999).
Additional info: Reacts with the 57kD alpha 6 subunit of rat GABA-A. There is no known reactivity with other GABA subunits. Species Crossreactivity: mouse. Other species have not been tested.

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