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GABA(A) Receptor, delta (Gamma-aminobutyric Acid Receptor Subunit delta, GABA(A) Receptor Subunit delta, GABAA-RD, Gabrd, MGC105467)

GABA(A) Receptor, delta (Gamma-aminobutyric Acid Receptor Subunit delta, GABA(A) Receptor Subunit delta, GABAA-RD, Gabrd, MGC105467)

Cat no: G1015-19Q

Supplier: United States Biological
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Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABA A Receptor (GABA A-R) subtype. GABA A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA A-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABA A-Rs sensitive to GABA. However, co-expression of a g-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P
Catalogue number: G1015-19Q
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Gamma-aminobutyric Acid (GABA) A Receptor, delta
References: 1. Korpi ER, Mihalek RM, Sinkkonen ST, Hauer B, Hevers W, Homanics GE, Sieghart W, Luddens H (2002) Altered receptor subtypes in the forebrain of GABAA receptor
Additional info: Recognizes rat GABA A. Species Crossreactivity: mouse.

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