GABA-B-R1 Antibody

Cat no: 251185

Supplier: ABBIOTEC

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Description
Additional Information

GABA-B-R1 is a receptor for GABA. The activity of GABA-B-R1 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. GABA-B-R1 plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decreases neuronal e, Xenopus/Amphibian,citability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. GABA-B-R1 is not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep,Mouse,uscle rela, Xenopus/Amphibian,ation and antinociception.

Catalogue number:	251185
Reactivities:	Human, Mouse, Bovine, Canine, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q9UBS5
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term of human GABA-B-R1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; Gb1; GABBR1