GABA Receptor A, alpha 1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit, GABRA)

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.\nGABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.\n\nCellular Localization: Membrane; multi pass membrane protein.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G1015-09A

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Rat, Bov

Form

10mM HEPES 9Ph7.5), 150nM NaCl, 100ug/ml BSA and 50% glycerol

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Zezula, J., et al, Separation of alpha 1, alpha 2, and alpha 3 subunits of the GABA-A-benzodiazepine receptor complex by immunoaffinity chromatography. Brain Res., 563: 325-8, 1991.

Additional Info

Reacts with the 51kD alpha 1 subunit of rat brain GABA-A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits. Species Crossreactivity: This antibody reacts with rat and bovine. Other species have not been tested.

Alternative Names

EJM, Gaba receptor alpha 1 polypeptide, GABA(A) receptor, GABRA 1, GABRA1, Gamma aminobutyric acid (GABA) A receptor alpha 1