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GABA Receptor A, beta 3 (Gamma-aminobutyric Acid Receptor Type A beta 3 Subunit, GABRAb3, GABRB3, MGC9051)

GABA Receptor A, beta 3 (Gamma-aminobutyric Acid Receptor Type A beta 3 Subunit, GABRAb3, GABRB3, MGC9051)

Cat no: G1015-19B

Supplier: United States Biological
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GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G1015-19B
Reactivities: Human, Rat, Bovine
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: 10mM HEPES [pH7.5] with 150 mM NaCl, 100ug/ml BSA & 50 % glycerol.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Slany, A., et al. Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35-S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric acid type A receptors. Mol. Pharmacol. 48: 385-91, 1995 2. Maison, S. F., Rosahl, T. W., Homanics, G. E., and Liberman, M. C. (2006) Functional Role of GABAergic Innervation of the Cochlea: Phenotypic Analysis of Mice Lacking GABAA Receptor Subunits {alpha}1, {alpha}2, {alpha}5, {alpha}6, beta2, beta3, or {delta}, 26, 10315-10326.
Additional info: Reacts with the 51-56kD beta 3 subunit of rat brain GABA-A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits. Species Crossreactivity: human and bovine. Other species have not been tested.

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