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GABABR2 Antibody

GABABR2 Antibody

Cat no: 251656

Supplier: ABBIOTEC
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Gamma-aminobutyric acid type B receptor subunit 2 (GABABR2) is a receptor for GABA. The activity of GABABR2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium-channels and modulate inositol phospholipid hydrolysis. GABABR2 plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABABR2 inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABABR2 decreases neuronal e, Xenopus/Amphibian,citability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. GABABR2 is not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep,Mouse,uscle rela, Xenopus/Amphibian,ation and antinociception.
Catalogue number: 251656
Reactivities: Human, Mouse, Bovine, Canine, Chicken/Bird, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: O75899
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GABABR2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: GABABR2; GABA-B receptor 2; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B-R2; GABA-BR2; Gb2; G-protein coupled receptor 51; HG20; GABBR2; GPR51; GPRC3B
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