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GABABR2 (Ser892) Antibody

GABABR2 (Ser892) Antibody

Cat no: 252544

Supplier: ABBIOTEC
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Gamma-aminobutyric acid type B receptor subunit 1 (GABA-Receptor, R-2 subunit), together with the GABA-Receptor, R-1 subunit, forms a receptor for GABA. The activity of GABA-B-Receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activates potassium channels, inactivate voltage-dependent calcium-channels and modulate inositol phospholipids hydrolysis. The GABA-B-Receptor plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-Receptors inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-Receptor decrease neuronal e, Xenopus/Amphibian,citability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. The GABA receptor has not only been implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep,Mouse,uscle rela, Xenopus/Amphibian,ation and antinociception. Phosphorylation of Ser783 plays a critical role in enhancing neuronal survival after ischemia.
Catalogue number: 252544
Reactivities: Human, Mouse, Bovine, Chicken/Bird, Xenopus/Amphibian, Zebrafish/Fish
Applications: Western Blot
Size: 0.1 ml
Accession: O88871
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser892 of rat GABAB receptor, R2-subunit.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
P type: Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody
Isotype: Rabbit IgG
Additional info: Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; Gabbr2; Gpr52
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