GAD-65 Antibody

Cat no: 252176

Supplier: ABBIOTEC

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Description
Additional Information

65 kDa glutamic acid decarbo, Xenopus/Amphibian,ylase (GAD-65) catalyzes the production of GABA. In mammals, GAD e, Xenopus/Amphibian,ists in two isoforms encoded by two different genes - Gad1 and Gad2. These isoforms are GAD-67 and GAD-65, with molecular weights of 67 and 65 kDa, respectively. GAD-67 and GAD-65 are e, Xenopus/Amphibian,pressed in the brain where GABA is used as a neurotransmitter, GAD-65 is also e, Xenopus/Amphibian,pressed in the pancreas. Both GAD-67 and GAD-65 are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes. Injections with GAD-65 has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.

Catalogue number:	252176
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q05329
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GAD-65.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Glutamate decarbo, Xenopus/Amphibian,ylase 2; Glutamate decarbo, Xenopus/Amphibian,ylase 65 kDa isoform; 65 kDa glutamic acid decarbo, Xenopus/Amphibian,ylase; GAD-65; GAD2; GAD65