GADD 45gamma (S123) Peptide

Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45beta and GADD 45gamma , have been shown to be induced by environmental stresses. GADD 45beta and GADD 45gamma are thought to induce p38/JNK activation via MEKK4 activation.

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SPECIFICATIONS

Catalog Number

BS9140P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide GADD 45gamma (S123). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O95257

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS9140 GADD 45gamma (S123) pAb.

Alternative Names

CR6; Cytokine responsive protein CR6; Cytokine-responsive protein CR6; DDIT-2; DDIT2; DNA damage-inducible transcript 2 protein; GA45G; Gadd45g; Growth arrest and DNA damage inducible gamma; Growth arrest and DNA damage-inducible protein GADD45 gamma; GRP17;