GADD 45gamma (S123) Peptide

Cat no: BS9140P

Supplier: Bioworld Technology, Inc.

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Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45beta and GADD 45gamma , have been shown to be induced by environmental stresses. GADD 45beta and GADD 45gamma are thought to induce p38/JNK activation via MEKK4 activation.

Catalogue number:	BS9140P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O95257
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide GADD 45gamma (S123). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	CR6; Cytokine responsive protein CR6; Cytokine-responsive protein CR6; DDIT-2; DDIT2; DNA damage-inducible transcript 2 protein; GA45G; Gadd45g; Growth arrest and DNA damage inducible gamma; Growth arrest and DNA damage-inducible protein GADD45 gamma; GRP17;
Additional info:	This peptide can be used with studies using BS9140 GADD 45gamma (S123) pAb.

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GADD 45gamma (S123) Peptide

Cat no: BS9140P

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