GalR1 is a Galanin Receptor that mediates the effects of the peptide galanin in a wide variety of tissues. Unlike GalR2, the primary signaling mechanism of GalR1 is by inhibiting adenylate cyclase through Gi. GalR1 regulates the GnRH neuroendocrine axis with its expression in POMC neurons. Pathogens like E. coli can cause diarrhea by increasing expression of Galanin Receptor 1 in the epithelial cells lining the colon, resulting in increased secretion of colonocyte chloride and fluid. GalR1 has been reported in brain, spinal cord, small intestine, colon, and eye. ESTs have been isolated from nerve and fetal lung/testis/B-cell libraries.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 19ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human Brain, Neurons
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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