Galanin Receptor 1 (GALR1)

Galanin is a 29aa C-terminally amidated (30aa, non-amidated in humans), highly conserved but unique neuroendocrine peptide originally isolated from intestine. The first 14aa are fully conserved in almost all species. Galanin is found in the brain and the gut. It modulates a variety of physiological processed including cognition/memory, sensory/pain processing, neurotransmitter/hormone secretion, and feeding behavior. Several N-terminally elongated (-7-29 and -9-29) or truncated biologically active forms of galanin have also been isolated. Galanin antagonists are chimeric peptides generated by linking the amino terminal portion of galanin to substance P (galantide, M15), bradykinin (M35), the neurokinin antagonist spantide (C7) or an idealized alpha helical region (M40) (see review in refs 2 by Kask et al 1995). Galanin mediated its biological effects by interacting with high affinity cell surface G-protein coupled receptors (GALR1-3). \n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:10-1:1000,000 (Coat with 50-100ng Control Peptide/well).\nWestern Blot: 1:1000-1:5,000\nOptimal dilutions to be determined by the researcher.\n\nRecommended Control Peptide:\nG1043-05H: Galanin Receptor 1, Mouse (GALR1) (Control Peptide)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G1043-05A

Size

50ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Wang S et al (1997) FEBS Lett. 411, 225-230. 2. Parker EM et al (1995) Brain Res. Mol. Brain Res. 34, 179-189. 3. Habert-Ortoli E et al (1994) PNAS 91, 9780-9783. 4. Lorimer DD et al (1997) BBRC 241, 558-564. 5. Jacoby AS et al (1997) Genomics 45, 496-508.

Additional Info

Recognizes mouse Galanin Receptor 1. No significant homology is seen with GLAR2, GALR3 or any other G-protein coupled receptors.