Galanin Receptor 3 (GALR3)

GalR3 is a Galanin Receptor that is similar, but distinct from the other galanin receptors, and it mediates the effects of the galanin peptide in a wide variety of tissues. Like GalR1, the signaling mechanism is predominantly through inhibition of adenylate cyclase. GalR3 has been reported in brain, testis, adrenal gland, and pancreas. An EST has been isolated from an ovarian thecoma fibroma library.\n\nGene Symbol:\nGALR3\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: ~37kD band observed in human skin and human testes lysates.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nHuman Skin Protein antigen standard for GALR3 (NM_003614) (transient overexpression lysate)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G1044-53

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hokfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H, Walker MW, Craig DA, Gerald CP, Branchek TA. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. Epub 2005 Nov 15. PMID: 16287967 Other PMIDs: 11867941

Additional Info

Species Crossreactivity: Human. Other species not tested.

Alternative Names

OTTHUMP00000028820, Galanin receptor, family member 3