Galectin-3 (Galactose-specific Lectin 3, Galectin 3, GAL3, Gal-3, 35kD Lectin, Carbohydrate Binding Protein 35, CBP 35, CBP35, Galactoside Binding Protein, GALBP, GALIG, IgE Binding Protein, L31, L-31, Laminin Binding Protein, Lectin Galactoside Binding S

Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas. Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions. \nThe monoclonal antibody inhibits the binding of 125I-labeled galectin-3 to IgE coated on microtiter plates, the galecin-3

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SPECIFICATIONS

Catalog Number

G1044-50G

Size

100ug

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.1% BSA.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Liu, F et al; Modulation of functional properties of galectin-3 by monoclonal antibodies binding to the non-lectin domains. Biochemistry 1996, 35: 6073 2. Sano, H et al; Human galectin-3 is a novel chemoattractant for monocytes and macrophages. J Immunol 2000, 165: 2156 3. Feilchenfeldt, J et al; Expression of galactin-3 in normal and malignant thyroid tissue by quantitative PCR and immunohistochemistry. Mod Pathol 2003, 16: 1117

Additional Info

Recognizes human Galectin-3, a 30kD protein. The epitope is found within the first 45aa of galectin-3. Does not react with Galecin-3C. Species Crossreactivity: Mouse

Alternative Names

35kD Lectin, Carbohydrate-binding Protein 35, Galactose Specific Lectin 3, Galactoside-binding Protein, IgE-binding Protein, Laminin-binding Protein, Lectin Galactoside-binding Soluble 3, LGALS2, MAC 2 Antigen