Ganciclovir (GCV, 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]6H-purin-6-one)

Supplier:

United States Biological

Cat no: G2004-40

Ganciclovir (GCV, 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]6H-purin-6-one)

Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.\n\nMelting Point: \n245-248C\n\nSolubility: \nDMSO, Methanol (sparingly), water (sparingly)\n\nMethod for Determining Identity:\nProton NMR Spectroscopic Analysis\n\nTLC Conditions:\nSiO2; Isopropanol; Water: NH4OH; 6:1:1; Visualized with UV and AMCS; single spot; Rf=0.36.\n\nStorage and Stability: \nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G2004-40

Size

100mg

Form

Supplied as a white solid

Purity

~90%

References

1. J. Med. Virol. 70(2): 240-243 (2003). 2. J. Clin. Exp. Immunol. 129(1): 19-26 (2002). 3. J. Med. Virol. 65(3): 537-542 (2001). 4. J. Virol. 72(8): 57-64 (1998). 5. AIDS Res. Hum. Retroviruses 14(6): 533-536 (1998). 6. J. Infect. Dis. 175(1): 179-184 (1997). 5.Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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