Ganglioside GM1 (Monosialoganglioside

A member of the family of glycosphingolipids, monosialoganglioside acts as a receptor and antigen for cholera. GM1 ganglioside, one of the glycosphingolipids widely distributed in all tissues, occurs in highest concentrations in the central nervous system (CNS). It is primarily located in the outer surface of the mammalian cell's plasma membrane and in synaptic membranes of the CNS. GM1 ganglioside modulates a number of cell surface and receptor activities as well as neuronal differentiation and development, protein phosphorylation and synaptic function.\n\nApplications: \nSuitable for use in ELISA and TLC immunoblotting. Other applications have not been tested.\n\nRecommended Dilutions: \nELISA: 1:1000\nTLC: 1:100\nNote: Dilution in PBS, pH 7.4, is recommended.\nOptimal dilutions to be determined by the researcher\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G2006-11

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Bov

Form

Supplied as a liquid. No preservative added. Glycerol free.

P Type

Pab

Purity

Serum

Isotype

IgG+IgM

References

1. Yoshino, H., et al., J. Neurochemistry 61: 658 (1993). 2. Kusunoki, S., et al., Neurology 37: 1795 (1987). 3. H. Yoshino, et al. Journal of Neurochemistry, Vol. 59(5):1684, 1992 4. A. Pestronk et al., Neurology, Vol. 49:1289, 1997

Additional Info

Recognizes bovine ganglioside GM1. Does not crossreact with other carbohydrate epitopes. Species Crossreactivity: Expresses some reactivity to asialo GM1 due to the natural background in rabbit. Expected to recognize GM1 ganglioside in most species with protein present.