Ganglioside GQ1b, Bovine (Tetrasialoganglioside GQ1b)

Supplier:

United States Biological

Cat no: G2006-80A

Ganglioside GQ1b, Bovine (Tetrasialoganglioside GQ1b)

Gangliosides, specialized sialic acid-containing glycolipids found abundantly in the outer leaflet of the neural phospholipid bilayer membrane, have a profound effect on tumor cells\nwhich prompts investigation. Mammalian tumors have exhibited drastic abnormalities in ganglioside profile. Gangliosides of normal murine neural tissue and murine neural tumor\ntissue were extracted through dissolution in both chloroform:methanol- and water-based solutions, isolated using Folch partitioning of polar lipids and non-polar lipids, and purified using ion exchange chromatography and desalting procedures. Ganglioside content was quantified using a Resorcinol assay, yielding a drastic disparity between normal neural tissue and tumor tissue. The distribution of specific gangliosides in the samples were analyzed using high performance thin-layer chromatography, showing a greater proportion of the more structurally complex gangliosides (e.g., GD1a, GT1b) in the healthy murine neural tissue and a greater proportion of the structurally simple gangliosides (e.g., GM3) in the murine neural tumor tissue. These results suggest a role of gangliosides in tumor proliferation and the possible use of the ganglioside profile as a diagnostic tool in cancer therapy.\n\nSolubility: \nSoluble in chloroform/methanol,/water (2:1:0.1). Forms micellar solution in water.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume by adding sterile buffer. Aliquot and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G2006-80A

Size

100ug

Form

Supplied as a white lyophillized powder in ammonium salt.

Purity

~98% (TLC)

References

1. Ecsedy J. A., Manfredi M. G., Yohe H. C., and Seyfried T. N.: Ganglioside Biosynthesis Gene Expression in Experimental Mouse Brain Tumors. Cancer Research. (Vol. 57, 15 April 1997): 1580-3. 2. El-Abbadi M. and Seyfried T. N.: Influence of Growth Environment on the Ganglio-side Composition of an Experimental Mouse Brain Tumor. Molecular and Chemical Neuropathology. (Vol. 21, 1994): 273-85. 3. Ledeen, Robert W.: The Chemistry of Gangliosides. Journal of the American Oil Chemists

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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