GAP-43 Antibody

Cat no: 250658

Supplier: ABBIOTEC

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Description
Additional Information

GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic a, Xenopus/Amphibian,onal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC,PorcineIP2, actin, calmodulin, spectrin,Porcinealmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.

Catalogue number:	250658
Reactivities:	Human, Mouse, Bovine, Chicken/Bird, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P17677
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GAP-43.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	GAP-43; Growth-associated protein 43; Neuromodulin; A, Xenopus/Amphibian,onal membrane protein GAP-43; PP46; Neural phosphoprotein B-50; GAP43