Gap-43 (Ser41) Antibody

Cat no: 252546

Supplier: ABBIOTEC

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Description
Additional Information

GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic a, Xenopus/Amphibian,onal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC,PorcineIP2, actin, calmodulin, spectrin,Porcinealmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.

Catalogue number:	252546
Reactivities:	Human, Mouse, Bovine, Chicken/Bird, Xenopus/Amphibian, Zebrafish/Fish
Applications:	Western Blot
Size:	0.1 ml
Accession:	P07936
Antigen:	KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser41 of rat Gap-43.
Format:	Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody
Isotype:	Rabbit IgG
Additional info:	GAP-43; Growth-associated protein 43; Neuromodulin; A, Xenopus/Amphibian,onal membrane protein GAP-43; PP46; Neural phosphoprotein B-50; GAP43