GAPDH, Recombinant, Human (Glyceraldehyde-3-phosphate Dehydrogenase, Peptidyl-cysteine S-nitrosylase GAPDH, GAPD, CDABP0047, OK/SW-cl.12)

Supplier:

United States Biological

Cat no: G8140-14E

GAPDH, Recombinant, Human (Glyceraldehyde-3-phosphate Dehydrogenase, Peptidyl-cysteine S-nitrosylase GAPDH, GAPD, CDABP0047, OK/SW-cl.12)

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a catalytic enzyme commonly known to be involved in glycolysis. The enzyme exists as a tetramer of identical 37kD subunits. GAPDH catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehydes 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, this ubiquitously expressed enzyme also displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling (1-5). Other studies also provide evidence of GAPDH playing an essential part of the program of gene expression observed in apoptosis and as part of the cellular phenotype of age-related neuro-degenerative diseases (6-7).\n\nSource:\nRecombinant corresponding to aa1-335, from human GAPDH, expressed in E.coli.\n\nMolecular Weight:\n~35.9kD\n\nSpecific Activity:\n35.7U/mg (One unit of activity of GAPDHis defined as the amount of enzyme required to convert 1 umole of NAD to NADH per minunder standard assay conditions)\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8140-14E

Size

500ug

Form

Supplied as a lyophilized powder in 20mM HEPES, pH7.4. Reconstitute with sterile dH2O PBS.

Purity

~95% (SDS-PAGE)

References

1. Baxi, M. D. and Vishwanatha, J. K. (1995) Biochemistry. 34, 9700-9707. 2. McNulty, S. E. and Toscano, W. A. Jr. (1995) Biochem. Biophys. Res. Commun. 34, 165-171. 3. Singh, R. and Green, M. R. (1993) Science.259, 365-368. 4. Zang, W. Q. et al. (1998) Virology. 28, 46-52. 5. Han, X. et al. (1998) Biochem. Biophys.Acta. 1414, 95-107. 6. Kragten, E. et al. (1998) J. Biol. Chem.273, 5821-5828. 7. Koshy, B. (1996) Hum. Mol. Genet. 5, 1311-1318. 8. Bagui, S. et al. (1999) Eur. J. Biochem. 262(2), 386-395.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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