GATA-4 belongs to the GATA family of transcription factors, which bind to the consensus DNA
sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and
morphogenesis. It is widely expressed in mesodermal- and endodermal-derived tissues. GATA-4
interacts with other transcription factors such as NKX2.5, and myocyte enhancer factor 2 to
regulate cardiac myocyte-specific gene expression. GATA-4 contains 2 zinc finger-binding
domains and migrates at 56kD in SDS-PAGE gels. Human GATA-4 share 93%, 93% and
92% aa sequence identity with porcine, rat and mouse GATA-4, respectively.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 0.5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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