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GATA6 (A403) (GATA Binding Factor 6, GATA Binding Protein 6, GATA-GT1, Transcription Factor GATA-6)

GATA6 (A403) (GATA Binding Factor 6, GATA Binding Protein 6, GATA-GT1, Transcription Factor GATA-6)

Cat no: G2021-56B

Supplier: United States Biological
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GATA proteins comprise a group of transcription factors that are related by the presence of conserved zinc finger DNA binding domains, which bind directly to the nucleotide sequence core element GATA (1-3). There are six vertebrate GATA proteins, designated GATA-1 to GATA-6 (3). GATA-6 plays a critical role in endoderm development (4). It is essential for development of the heart, gut and other organs (5,6). Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm (4). Loss of expression, or loss of nuclear localization of GATA-6 is apparent in a large number of ovarian tumors (7). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2021-56B
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Ko, L.J. and Engel, J.D. (1993) Mol Cell Biol 13, 4011-22, 2. Merika, M. and Orkin, S.H. (1993) Mol Cell Biol 13, 3999-4010, 3. Lowry, J.A. and Atchley, W.R. (2000) J Mol Evol 50, 103-15, 4. Cai, K.Q. et al. (2008) Dev Dyn 237, 2820-9, 5. Charron, F. and Nemer, M. (1999) Semin Cell Dev Biol 10, 85-91, 6. Haveri, H. et al. (2008) BMC Gastroenterol 8, 9, 7. Caslini, C. et al. (2006) Oncogene 25, 5446-61.
Additional info: Recognizes endogeneous levels of total human GATA-6 (A403) at ~55kD.

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