Home  >  Products  >  GBL (Target of Rapamycin Complex Subunit LST8, TORC Subunit LST8, G Protein beta Subunit-like, Gable, Protein GbetaL, Mammalian Lethal with SEC13 Protein 8, mLST8, MLST8, LST8)
GBL (Target of Rapamycin Complex Subunit LST8, TORC Subunit LST8, G Protein beta Subunit-like, Gable, Protein GbetaL, Mammalian Lethal with SEC13 Protein 8, mLST8, MLST8, LST8)

GBL (Target of Rapamycin Complex Subunit LST8, TORC Subunit LST8, G Protein beta Subunit-like, Gable, Protein GbetaL, Mammalian Lethal with SEC13 Protein 8, mLST8, MLST8, LST8)

Cat no: G8600-02V

Supplier: United States Biological
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LST8, a 36-40kD intracellular protein, is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin-receptor activation including insulin-stimulated glucose transport and glycogen synthesis. Northern Blot analysis detected a ubiquitous expression of LST8 with highest expression in brain and testis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-02V
Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken/Bird
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Rodgers et.al J Endocrinology 168 (2) 325-332 (February 2001) 2. Kim et.al Mol. Cell 11 (4) 895-904 (April 2003).
Additional info: Recognizes human GBL. Species Crossreactivity: bovine, chicken, chimpanzee, canine, mouse, rat, rhesus monkey. Species sequence homology: xenopus.

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