GCDFP15 (Prolactin-inducible Protein, Gross Cystic Disease Fluid Protein 15, GCDFP-15, Prolactin-induced Protein, Secretory Actin-binding Protein, SABP, gp17, PIP, GPIP4)

Human breast gross cystic disease is a common benign breast disease which occurs most frequently in the age range of 40-50 years, then becomes very infrequent after menopause. It is characterized by production of a unique fluid secretion which accumulates in the breast cysts composed of several glycoproteins, including a unique 15kD monomer protein, GCDFP-15. The protein is present in normal apocrine epithelium, metaplastic apocrine epithelium of the breast, and breast carcinomas with apocrine features. The protein is regarded as a specific functional marker of apocrine cells. It is expressed during fetal development and may represent a common marker of embryologically linked glandular structures. The gene coding for GCDFP-15 is localized in the long arm of chromosome 7.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (formalin fixed paraffin embedded): 1:10-1:20\nImmunohistochemistry: Frozen\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nSkin\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G2023-25A

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG2a

References

1. Hall et al. British Journal of Cancer 78: 360, 1998. 2. Silloo et al. Modern Pathology 11: 1038, 1998. 3. Viacava et al. Virchows Arch 432: 255, 1998. 4. Mazoujia et al. American Journal of Pathology 116: 305, 1984.

Additional Info

Recognizes human GCDFP15.