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GDF-15 (L64) pAb

GDF-15 (L64) pAb

Cat no: BS3872

Supplier: Bioworld Technology, Inc.
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Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-(beta), is a member of the transforming growth factor beta (TGF-beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer, and may be a means of diagnosis.
Catalogue number: BS3872
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q99988
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 32-80 of Human GDF-15.
Species: GDF-15 (L64) pAb detects endogenous levels of GDF-15 protein.
Molecular weight: ~ 37 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: anti-GDF15 antibody; GDF-15 antibody; MIC-1 antibody; MIC1 antibody; NAG-1 antibody; NRG-1 antibody; PDF antibody; PLAB antibody; PTGFB antibody
Additional info: For research use only, not for use in diagnostic procedure.

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