GDNF BioAssay(TM) ELISA Kit, Human

Supplier:

United States Biological

Cat no: 143850

GDNF BioAssay(TM) ELISA Kit, Human

Sandwich ELISA quantitative detection kit for Human GDNF in cell culture supernates, serum and plasma (heparin, EDTA).\n\nGlial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily.1 GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures.2 GDNF, in addition to its potential role in the differentiation and survival of central nervous system neurons, has profound effects on kidney organogenesis and the development of the peripheral nervous system.3 GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.1 GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3 ability to promote dopamine uptake in midbrain cultures.2 \n\nAssay Range:\n31.2pg/ml-2000pg/ml\n\nSensitivity:\n< 4 pg/ml\n\nCrossreactivity:\nThere is no detectable cross-reactivity with other relevant proteins.\n\nUniprot ID:\nP39905\n\nEntrez Gene ID:\n2668\n\nKit Components:\n96-well plate pre-coated with anti-GDNF, Human\nLyophilized recombinant GDNF, Human standard, 10ng/tube, 2Ea\nUSB Cat No Kit Component\n143696 Avidin-Biotin-Peroxidase Complex (ABC), 130ul (1:100 dilution)\n143697 Sample diluent buffer, 30ml\n143698 Antibody diluent buffer, 12ml\n143699 ABC diluent buffer, 12ml\n143700 TMB color developing agent, 10ml\n143701 TMB stop solution, 10ml\n\nStorage and Handling:\nStore at 4 degrees C for 6 months, at -20 degrees C for 12 months. Avoid multiple freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

143850

Size

96Tests

References

1. Lin, L.-F. H.; Doherty, D. H.; Lile, J. D.; Bektesh, S.; Collins, F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132, 1993. \n2. Bermingham, N.; Hillermann, R.; Gilmour, F.; Martin, J. E.; Fisher, E. M. Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5. Hum. Genet. 96: 671-673, 1995.\n3. Durbec, P.; Marcos-Gutierrez, C. V.; Kilkenny, C.; Grigoriou, M.; Wartiowaara, K.; Suvanto, P.; Smith, D.; Ponder, B.; Costantini, F.; Saarma, M.; Sariola, H.; Pachnis, V. GDNF signalling through the Ret receptor tyrosine kinase. Nature 381: 789-793, 1996. \n

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

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