Home  >  Products  >  Gelsolin (Actin depolymerizing factor, ADF, AGEL, Amyloidosis Finnish type, Brevin, DKFZp313L0718, GSN, Calcium regulated actin binding protein)
Gelsolin (Actin depolymerizing factor, ADF, AGEL, Amyloidosis Finnish type, Brevin, DKFZp313L0718, GSN, Calcium regulated actin binding protein)

Gelsolin (Actin depolymerizing factor, ADF, AGEL, Amyloidosis Finnish type, Brevin, DKFZp313L0718, GSN, Calcium regulated actin binding protein)

Cat no: G2024-53F

Supplier: United States Biological
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Gelsolin is a large and complex actin-binding protein that belongs to actin-severing gelsolin/villin super family. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2). Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-5000 Immunohistochemistry: 1:100-250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: G2024-53F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Sun, H et al. J Biol Chem 274 (47): 33179
Additional info: Recognizes human Gelsolin.

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