Gelsolin Antibody

Cat no: 251529

Supplier: ABBIOTEC

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Description
Additional Information

Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments,Porcinereventing monomer e, Xenopus/Amphibian,change (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Catalogue number:	251529
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P06396
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human gelsolin.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Gelsolin; Actin-depolymerizing factor; ADF; Brevin; AGEL; GSN