Gelsolin Antibody

Cat no: 251751

Supplier: ABBIOTEC

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Description
Additional Information

Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus ends of actin monomers and filaments,Porcinereventing monomer e, Xenopus/Amphibian,change. Gelsolin promotes the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition, and is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals, causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Catalogue number:	251751
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P06396
Antigen:	Human plasma gelsolin.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	GEL-42
Additional info:	Gelsolin; Actin-depolymerizing factor; ADF; Brevin; AGEL