Gelsolin is a calcium and polyphosphoinositide regulated actin-binding protein which consists of 6 homologous domains. It is involved in cell morphology, motility, growth and apoptosis through its ability to affect filament assembly by severing actin filaments, forming a nucleus for polymerisation, and capping the fast exchanging end of the filaments. It exists as an intracellular form, found in the cytoplasm and mitochondria, and an extracellular form located in blood plasma.
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilutions:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.