Gemcitabine Hydrochloride (2

Supplier:

United States Biological

Cat no: G2024-53A

Gemcitabine Hydrochloride (2

Gemcitabine is a nucleoside analog of deoxycytidine used as chemotherapy to treat patients with various types of cancer. After passage through the cell membrane via nucleoside transporters, gemcitabine undergoes complex intracellular conversion to gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP). dFdCTP inhibits DNA polymerase by competing with deoxycytidine triphosphate (dCTP). dFdCDP inhibits ribonucleoside reductase and DNA synthesis by causing depletion of deoxyribonucleotide pools, and thus potentiating the effects of dFdCTP. Gemcitabine can be inactivated to 2,2'-difluorodeoxyuridine, mainly by deoxycytidine deaminase. Also, 5'-nucleotidase catalyses the conversion of nucleotides to nucleosides and inhibits nucleoside kinases.\n\nSolubility:\nSoluble in DMSO at 12.5mg/ml with slight warming; very poorly soluble in ethanol; soluble in water at 25mg/ml with slight warming; buffers, serum, or other additives may increase or decrease the aqueous solubility.\n\nElemental Analysis:\nCalculated:\nC: 36.07%\nH: 4.04%\nCl: 11.83%\nF: 12.68%\nN: 14.02%\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G2024-53A

Size

100mg

Form

Supplied as a white powder

Purity

~99%

References

1. Mini, E., et al. \"Cellular pharmacology of gemcitabine.\" Ann. Oncol. 17:v7-v12 (2006). 2. Cartwright, T., et al. \"Cancer of the pancreas: are we making progress? A review of studies in the US Oncology Research Network.\" Cancer Control 15:308-313 (2008). 3. Huang, P., et al. \"Action of 2',2'-difluorodeoxycytidine on DNA synthesis.\" Cancer Res. 51:6110-6117 (1991). 4. Cappella, P., et al. \"Cell cycle effects of gemcitabine.\" Int. J. Cancer 93:401-408 (2001). 5. Sun, D., et al. \"Enhancement of DNA ligase I level by gemcitabine in human cancer cells.\" Clin. Cancer Res. 8:1189-1195 (2002).

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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