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Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, RP3 369A17.3)

Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, RP3 369A17.3)

Cat no: G2024-55D

Supplier: United States Biological
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Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex. It is degraded during the mitotic phase of the cell cycle, has a destruction box sequence (RRTLKVIQP), and is ubiquitinated by the anaphase promoting complex in vitro. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Further, geminin interacts tightly with CDT1, a replication initiation factor necessary for MCM loading. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G2024-55D
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Tris-citrate/phosphate buffer, pH 7 to 8
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, OTTHUMP00000039393, RP3 369A17.3
Additional info: Species Crossreactivity: Human. Other species not tested.

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