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Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, RP3 369A17.3)

Geminin (GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, RP3 369A17.3)

Cat no: G2024-55E

Supplier: United States Biological
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Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex. It is degraded during the mitotic phase of the cell cycle, has a destruction box sequence (RRTLKVIQP), and is ubiquitinated by the anaphase promoting complex in vitro. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Further, geminin interacts tightly with CDT1, a replication initiation factor necessary for MCM loading. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunoprecipitation: 2-5ug/mg lysate Western Blot: 1:2000-1:10,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2024-55E
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7.5, 0.09% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: GMNN, GEM, Geminin DNA Replication Inhibitor, DNA replication inhibitor, OTTHUMP00000039393, RP3 369A17.3
Additional info: Recognizes human Geminin. The epitope maps to a region between residue 160 and the C-terminus (residue 209) of human Geminin DNA replication Inhibitor using the numbering given in entry NP_056979.1 (GeneID 51053).

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