GFAP (Glial Fibrillary Acidic Protein)

Immunohistochemical studies have shown that GFAP is selectively located in astrocytes and represents the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. As differentiation proceeds, neurons are generated at the ventricular surface and then migrate along astrocytic processes toward their ultimate destination, whereas astrocytes provide the scaffolding and throphic support required for neuronal positioning. Astrocytes and oligodendrocytes together make up half the cell content in human brain. In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer

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SPECIFICATIONS

Catalog Number

G2032-27D

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. No stabilizing proteins added.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

Van Muijen, GN, Ruiter, DJ, and Warnaar, SO - Coexpression of intermediate filament polypeptides in human fetal and adult tissues. Lab Invest 57: 359-69 (1987).

Additional Info

Recognizes human glial fibrillary acidic protein (GFAP) which is present in astrocytes in the central nervous system and Schwann cells.