GFAP, Human (Glial Fibrillary Acidic Protein)

Supplier:

United States Biological

Cat no: G2032-33B

GFAP, Human (Glial Fibrillary Acidic Protein)

Protein (GFAP), as a member of the cytoskeletal protein family, is the principal 8-9nm intermediate filament in mature astrocytes of the central nervous system (CNS). GFAP is a monomeric molecule with a molecular mass between 40 and 53kD and an isoelectric point between 5.7 and 5.8. GFAP is a highly brain-specific protein that is not found outside the CNS. Findings have shown that while GFAP is released into the blood very soon after traumatic brain injury (TBI) based on its severity, GFAP is not released after even multiple traumae in the absence of brain injury. In the CNS, following injury, either as a result of trauma, disease, genetic disorders, or chemical insult, astrocytes become reactive and respond in a typical manner, termed astrogliosis. Astrogliosis is characterized by the rapid synthesis of GFAP. GFAP normally increases with age and there is a wide variation in the collection and processing of human brain tissue. Thanks to its high brain specificity and early release from the CNS after TBI, GFAP might be a suitable marker for early diagnostics.\n\nMolecular Weight: ~46kD(major two bands). GFAP preparations were represented by several protein bands 43-49kD. The major two bands appear in the region of the 46kD.\n\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nMolecular Weight: 46,000 (major two bands). GFAP preparations were represented by several protein bands 43-49kD. The major two bands appear in the region of the 46kD.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G2032-33B

Size

50ug

Applications

WB

Form

Supplied as a suspension in 800mM urea, 1mM sodium phosphate, 16mM sodium bicarbonate. No preservative added.\n

Purity

~90% by 10% SDS-PAGE: Two staged tissue extraction, hydroxyapatite column puri?cation

References

1. Dahl, D., Brain Res. 57: 343-360 (1973). 2. Liem, R.K., Biochemistry 21: 3221 (1982).

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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