GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRa from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRa was also termed Ret ligand 1 (RETL1) or TGF-b-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa-1 recently (5-7). GFRa-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRa and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.\n\nThis polyclonal antibody can be used for detection of GFRa-1 by Western blot. The amino acid sequence of immunogenic peptide is identical to those of mouse and rat and the antibody recognizes GFRa-1 from human, mouse and rat origins.\n\nAntibody blocking peptide: G2033-01P.\n

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SPECIFICATIONS

Catalog Number

G2033-01

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified IgG

Isotype

IgG

References

1. Jing S; Wen D; Yu Y; Holst PL ; Luo Y; Fang M; Tamir R; Antonio L; Hu Z; Cupples R; Louis JC; Hu S; Altrock BW; Fox GM. GDNF-induced activation of the Ret protein tyrosien kinase is mediated by GDNFR-a, a novel receptor for GDNF. Cell, 1996;85: 1113-24. 2. Treanor JJS; GoodmanL; Sauvage FD; Stone DM; Poulsen KT; Beck CD; Gray C; Armanini MP; Pollock RA; Herti F; Phillips HS; Goddard A; Moore MW; Buj-Bello A;Davies AM; Asai N; Takahashi M; Vandlen R; Henderson CE; Rosenthal A. Characterization of a multicomponent receptor for GDNF. Nature, 1996;382: 80-83. 3. Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci U S. 1997;94: 6238-6243. 4. Buj-Bello A, Adu J, Pinon LG, Horton A, Thompson J, Rosenthal A, Chinchetru M, Buchman VL, Davies AM. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997;387: 721-724. 5. Dey,B.K., Wong,Y.W. and Too,H.P. Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor. Neuroreport 1998;9: 37-42. 6. Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, ZimonjicDB, Popescu NC, Johnson EM Jr, Milbrandt J. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 1997;18: 793-802. 7. Nomenclature Committee. Nomenclature of GPI-linked receptors for the GDNF ligand family. GFRa.. Neuron 1997;19: 485.

Additional Info

Recognizes human GFR alpha-1 (IN).