GFRA2 (GDNF Family Receptor alpha-2, GDNF Receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF Receptor beta, GDNFR-beta, Neurturin Receptor alpha, NRTNR-alpha, NTNR-alpha, RET Ligand 2, TGF-beta-related Neurotrophic Factor Receptor 2, GDNFRB, RETL2, TRNR2)

Cat no: G2033-28B

Supplier: United States Biological

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GFRa-2, also known as NTNRa, GDNFRb, Ret ligand 2 (RETL2) or TGFb-related neurotrophic factor receptor 2 (TNR2) binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. GDNF (glial cell line-derived neurotrophic factor) is a potent survival factor for central and peripheral neurons. Physiological responses to GDNF require the presence of a novel glycosylphophadidylinositol linked protein GDNFRa. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HeLa Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	G2033-28B
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	50ug
Form:	Supplied as a liquid in PBS, 0.02% sodium azide.
P type:	Pab
Isotype:	IgG
Purity:	Purified by Protein G affinity chromatography.
References:	1. Kotzbauer PT, Lampe PA, Heuckerothh RO, et al. Nature 384: 467-470 (1996). 2. Klein RD, Sherman D, Ho WH, Stone D, Bennet GL, et al. Nature 387: 717-721 (1997). 3. BujiBello A, Abu J, Pinon LG, Horton A, et al. Nature 387: 721-724 (1997). 4. Baloh RH, Tansey MG, Golden JP, Creedon DJ, et al. Neuron 18: 793-802 (1997).
Additional info:	Recognizes human GFRA2. Species Crossreactivity: mouse and rat.

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GFRA2 (GDNF Family Receptor alpha-2, GDNF Receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF Receptor beta, GDNFR-beta, Neurturin Receptor alpha, NRTNR-alpha, NTNR-alpha, RET Ligand 2, TGF-beta-related Neurotrophic Factor Receptor 2, GDNFRB, RETL2, TRNR2)

Cat no: G2033-28B

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