Home  >  Products  >  GFRA3, ID (GDNF Family Receptor alpha-3, GDNF Receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3, UNQ339/PRO538/PRO3664)
GFRA3, ID (GDNF Family Receptor alpha-3, GDNF Receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3, UNQ339/PRO538/PRO3664)

GFRA3, ID (GDNF Family Receptor alpha-3, GDNF Receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3, UNQ339/PRO538/PRO3664)

Cat no: G2033-53D

Supplier: United States Biological
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Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: 3T3 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2033-53D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Milbrandt, J. et al. Neuron 20, 245 (1998). 2. Nomeclature Committee. et al. Neuron 19, 485 (1997). 3. Jing, S. et al. J. Biol. Chem. 272, 33111 (1997). 4. Baloh, RH. et al. Proc. Natl. Acad. Sci. USA 95, 5801 (1998). 5. Worby, CA. et al. J. Biol. Chem. 273, 3502 (1998). 6 Naveilhan, P. et al. Proc. Natl. Acad. Sci. USA 95, 1295 (1998). 7. Nomoto, S. et al. Biochem. Biophys. Res. Commun. 244, 849 (1998).
Additional info: Recognizes mouse GFRa-3. Species Crossreactivity: human and rat.

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