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GGH (Gamma-Glutamyl Hydrolase, Conjugase GH Gamma-Glu-X Carboxypeptidase)

GGH (Gamma-Glutamyl Hydrolase, Conjugase GH Gamma-Glu-X Carboxypeptidase)

Cat no: G7201-01

Supplier: United States Biological
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Gamma-Glutamyl hydrolase (GGH) is a homodimeric protein that catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a central enzyme in folyl and antifolyl poly-gamma-glutamate metabolism. The activities of the baculovirus-expressed enzyme and the enzyme from HL-60 cells were similar on methotrexate polyglutamates. GGH is expressed in a variety of human tuomrs and correlates with poor prognosis. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HL-60, MCF cell line Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G7201-01
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Rhee,M.S., Lindau-Shepard,B., Chave,K.J., Galivan,J. and Ryan,T.J. Characterization of human cellular gamma-glutamyl hydrolase. Mol. Pharmacol. 53 (6), 1040-1046 (1998). 2. Yao,R., Schneider,E., Ryan,T.J. and Galivan,J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. 93 (19), 10134-10138 (1996). 3. He P, Varticovski L, Bowman ED, Fukuoka J, Welsh JA, Miura K, Jen J, Gabrielson E, Brambilla E, Travis WD, Harris CC. Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol. 35(10): 1196-1209 (2004).
Additional info: Recognizes human Gamma-Glutamyl hydrolase.

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