Ghrelin, Des, full length, Ser3, acylated, Human

Supplier:

United States Biological

Cat no: G2033-76

Ghrelin, Des, full length, Ser3, acylated, Human

Human full length des-ghrelin, 1-27-aa and n-octanoylated at ser3, peptide was synthesized and purified by hplc.\n\nGrowth hormone (GH), produced and released from the anterior pituitary, controls body growth, carbohydrate-protein-lipid metabolism and water-electrolyte balance. GH secretagogues (GHSs) are synthetic compounds that are potent stimulators of GH release. GHSs, act through a novel orphan G-protein-coupled receptor (GPCR), the GHS receptor (GHS-R). Ghrelin ('ghre' is the Proto-Indo-European root of the word "grow") has been purified and identified from rat and human stomach as the endogenous ligand for the GHS-R. The rat and human mature Ghrelin (28-aa) are produced from 117 amino acids precursor. In rat stomach, a 28-aa Ghrelin and des-Gln14-Ghrelin (deletion of Gln14) are produced due to alternative splicing of Ghrelin mRNA. The activity of both Ghrelins is the same. However, des-Gln14-Ghrelin is only present in low amounts in the stomach, indicating that Ghrelin is the major active form. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and it is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid.\n\nRat Ghrelin is expressed in the stomach, small and large intestines, and brain regions (hypothalamic arcuate nucleus) that are involved the regulation of food intake. Both Ghrelin and GHS-R expression is detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increasing food intake and reduction in fat utilization and anti-Ghrelin IgG administration suppressed feeding.

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SPECIFICATIONS

Catalog Number

G2033-76

Size

500ug

Applications

ELISA

Form

Supplied as a liquid in PBS, pH 7.2

Purity

Highly purified

References

(1) Kojima M et al (1999) Nature 402, 656; Hosoda H et al (2000) J. Biol. Chem. 275, 2199; Nakazato M et al (2001) Nature 409, 194; Tschop et al (2000) Nature 407; 908.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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