GIP, Recombinant, Human, aa22-153, His-Tag (Gastric Inhibitory Polypeptide)

Supplier:

United States Biological

Cat no: 137067

GIP, Recombinant, Human, aa22-153, His-Tag (Gastric Inhibitory Polypeptide)

GIP, also known as glucose-dependent insulinotropic polypeptide, is an important insulin-releasing hormone of the enteroinsular axis that has a functional profile of possible therapeutic value for type 2 diabetes. This protein is an important incretin hormone released into the circulation from endocrine K-cells of the duodenum and jejunum after ingestion of food1. It was evaluated for their ability to elevate cellular cAMP production and stimulate insulin secretion. It also promotes plasma triglyceride clearance in response to oral fat loading. In liver, GIP has been shown to enhance insulin-dependent inhibition of glycogenolysis. \n\nSource: \nRecombinant protein corresponding to human GIP, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~17.3kD (155aa) (MALDI-TOF) \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSEKKEGHF SALPSLPVGS HAKVSSPQPR GPRYAEGTFI SDYSIAMDKI HQQDFVNWLL AQKGKKNDWK HNITQREARA LELAGQANRK EEEAVEPQSS PAKNPSDEDL LRDLLIQELL ACLLDQTNLC RLRSR\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137067

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 50% glycerol 0.1M NaCl, 2mM DTT.

Purity

~90% (SDS-PAGE)

References

1. O'Harte FP. et al. (1999) Diabetes. 48:758-765. 2. Gault VA. et al. (2002) Biosci Rep. 22:523-528.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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