GIPC3 (PDZ Domain-containing Protein GIPC3, C19orf64)

GIPC proteins are multifunctional proteins which play a significant role in vesicular trafficking, signal transduction, cytoskeletal organization, embryogenesis and carcinogenesis. These are involved in multi-protein interactions which include C-terminus of GAIP/RGS19, FZD class of WNT receptor, IGF-1 receptor, TrkA, TGF-beta type III receptor, integrin alpha6A subunit, and a transmembrane glycoprotein 5T4. GIPC3, a 36kD protein, is a novel member of this family. It is a human ortholog to Xenopus Kermit and Drosophila LPO9416 and consists of a central PDZ domain, GH1 and GH2 domains and a C-terminal ACP domain. Northern Blot analysis and RNA dot blot analysis have detected a ubiquitous expression of GIPC3 in adult and fetal tissues, with an increased expression observed in small intestine, jejunum, parietal lobe of brain, lymph node, fetal liver and fetal thymus.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.2-1.5ug/ml\nELISA: >1:32,000\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman heart\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G2034-56A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Saitoh T, Mine T, Katoh M. Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2. Int J Oncol. 2002 Mar;20(3):577-82. PMID: 11836571 2. Katoh M Int J Mol Med. Jun; 9(6):585-9 (2002).

Additional Info

Recognizes human GIPC3.