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GIT1 (ARF GTPase-activating Protein GIT1, ARF GAP GIT1, G Protein-coupled Receptor Kinase-interactor 1, GRK-interacting Protein 1, Cool-associated and Tyrosine-phosphorylated Protein 1, CAT1, Cat-1)

GIT1 (ARF GTPase-activating Protein GIT1, ARF GAP GIT1, G Protein-coupled Receptor Kinase-interactor 1, GRK-interacting Protein 1, Cool-associated and Tyrosine-phosphorylated Protein 1, CAT1, Cat-1)

Cat no: G2035-07A

Supplier: United States Biological
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GIT1, also known as G protein-coupled receptor kinase interactor 1 variant, is a 774aa containing cytoplasmic protein belonging to the GIT protein family with an Arf-GAP domain. This regulatory protein is a GTPase-activating protein for the ADP ribosylation factor family and may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. It increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. GIT1 sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes and also plays a critical role in spine and synapse formation. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2035-07A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Manabe, R. et al. J. Cell Sci. 115:1497-1510 (2002). 2. Zhang, H. et al. J. Cell Biol. 161:131-142 (2003). 3. Goehler, H. et al. Molec. Cell. 15:853-865 (2004).
Additional info: Recognizes human GIT1. Species Crossreactivity: rhesus monkey. Species sequence homology: chimpanzee, bovine, canine, equine, mouse, rat.

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