GIT2 (D391) Peptide

Cat no: BS2056P

Supplier: Bioworld Technology, Inc.

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Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases(GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of beta2-adrenergic receptor, thus reducing beta2-adrenergic receptor signaling.

Catalogue number:	BS2056P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q14161
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide GIT2 (D391). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; KIAA0148; GIT2
Additional info:	This peptide can be used with studies using BS2056 GIT2 (D391) pAb.

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GIT2 (D391) Peptide

Cat no: BS2056P

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