Home  >  Products  >  GITR (Glucocorticoid-induced TNFR-related Protein, GITR-D, Activation-inducible TNFR Family Receptor, AITR, CD357, Tumor Necrosis Factor Receptor Superfamily Member 18, TNFRSF18, UNQ319/PRO364)
GITR (Glucocorticoid-induced TNFR-related Protein, GITR-D, Activation-inducible TNFR Family Receptor, AITR, CD357, Tumor Necrosis Factor Receptor Superfamily Member 18, TNFRSF18, UNQ319/PRO364)

GITR (Glucocorticoid-induced TNFR-related Protein, GITR-D, Activation-inducible TNFR Family Receptor, AITR, CD357, Tumor Necrosis Factor Receptor Superfamily Member 18, TNFRSF18, UNQ319/PRO364)

Cat no: G2035-08N

Supplier: United States Biological
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Glucocorticoid induced Tumor Necrosis Factor receptor family related gene (GITR, AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression (2). GITR has been implicated as a regulatory mechanism in parasitic immune resposes (4), and is involved with Macrophages activation in atherosclerotic plaque formation (3). Applications: Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2035-08N
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 100ug
Form: Supplied as liquid in 50mM sodium phosphate pH 7.5, 500mM potassium chloride, 150mM sodium chloride, 0.5mg/ml gentamicin sulfate.
P type: Mab
Isotype: IgM
Purity: Purified by Protein A affinity chromatography.
References: 1. Gurney AL, et al. (1999) Curr Biol 9(4): 215-218, Ji HB, et al. (2004 ) J Immunol 172(10): 5823-5827, Kim WJ, WH Lee, et al. (2006) Immunology 119(3): 44-9, 4. Furze RC, Selkirk ME, et al. (2006) Microbes Infect 8 (12-13): 2803-10, Kohm AP, SD Miller, et al. (2004) J Immunol 172: 4686-4690, McHugh, R.S. et al. (2002) Immunity 16:311, Shin, H.H. et al. (2002) FEBS Lett. 514:275, 8. Shimizu, J. et al. (2002) Nature Immunol. 3:135.
Additional info: Recognizes human recombinant GITR. Binds to human GITR in EIA and on stimulated cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

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