Home  >  Products  >  GITR (Glucocorticoid-induced TNFR-related Protein, GITR-D, Activation-inducible TNFR Family Receptor, AITR, CD357, Tumor Necrosis Factor Receptor Superfamily Member 18, TNFRSF18, UNQ319/PRO364) (PE)
GITR (Glucocorticoid-induced TNFR-related Protein, GITR-D, Activation-inducible TNFR Family Receptor, AITR, CD357, Tumor Necrosis Factor Receptor Superfamily Member 18, TNFRSF18, UNQ319/PRO364) (PE)

GITR (Glucocorticoid-induced TNFR-related Protein, GITR-D, Activation-inducible TNFR Family Receptor, AITR, CD357, Tumor Necrosis Factor Receptor Superfamily Member 18, TNFRSF18, UNQ319/PRO364) (PE)

Cat no: G2035-08W

Supplier: United States Biological
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Glucocorticoid induced Tumor Necrosis Factor receptor family related gene (GITR, AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression (2). GITR has been implicated as a regulatory mechanism in parasitic immune resposes (4), and is involved with Macrophages activation in atherosclerotic plaque formation (3). Applications: Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: G2035-08W
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 120 tests
Form: Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 500mM potassium chloride, 150mM sodium chloride, 0.2% BSA, 0.04% sodium azide, 5% glycerol. Labeled with R-Phycoerythrin (PE).
P type: Mab
Isotype: IgG3,k
Purity: Purified by Protein A affinity chromatography.
References: 1. Gurney AL, et al. (1999) Curr Biol 9(4): 215-218, Ji HB, et al. (2004 ) J Immunol 172(10): 5823-5827, Kim WJ, WH Lee, et al. (2006) Immunology 119(3): 44-9, 4. Furze RC, Selkirk ME, et al. (2006) Microbes Infect 8 (12-13): 2803-10, Kohm AP, SD Miller, et al. (2004) J Immunol 172: 4686-4690, McHugh, R.S. et al. (2002) Immunity 16:311, Shin, H.H. et al. (2002) FEBS Lett. 514:275, 8. Shimizu, J. et al. (2002) Nature Immunol. 3:135.
Additional info: Recognizes human GITR. Binds to human GITR in EIA and on stimulated cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

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