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GITRL (Glucocorticoid Induced TNF-Related Ligand, AITRL, Activation-Inducible TNF-Related Ligand, TNFSF18) (APC)

Cat no: G2035-15N

GITRL (Glucocorticoid Induced TNF-Related Ligand, AITRL, Activation-Inducible TNF-Related Ligand, TNFSF18) (APC)

A B Tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily members are regulators of diverse cellular functions such as proliferation, differentiation, and survival/apoptosis. The glucocorticoid-induced TNFR family-related protein (GITR, also known as TNFRSF18) is an inducible type I transmembrane protein that modulates T cell apoptosis. The human and mouse orthologs share 60% overall aa homology and exhibit three characteristic cysteine rich domains in the extracellular portion of the protein. The intracellular domains of human and mouse GITR are most similar to the TNFR family members 4-1BB, CD27, and OX40. GITR expression is induced on T cells upon activation with various stimuli. The induced expression of GITR appears to confer T cell resistance to anti-CD3 mAb-induced apoptosis. GITR is also expressed on a subset of regulatory T cells (Tregs). In addition, macrophages have also been described as expressing GITR.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nNSO myeloma cells with B cells from Balb/c mice. \n\nAbsorption: 620-650nm\n\nEmission: 660-670nm\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.

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SPECIFICATIONS

Catalog Number

G2035-15N

Size

100Tests

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2A

Additional Info

Recognizes mouse GITRL.

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